• Read more about Predictive Software-Based Mathematical Modeling: A Novel Approach to Development of Oral Therapies for Rheumatoid Arthritis – Validation in a Murine Collagen Induced Arthritis Model.

Predictive Software-Based Mathematical Modeling: A Novel Approach to Development of Oral Therapies for Rheumatoid Arthritis – Validation in a Murine Collagen Induced Arthritis Model

• Read more about Novel Combination Therapy of existing repurposed therapies, designed by predictive software modeling, shows profound impact on disease progression in a murine Collagen-Induced Arthritis (CIA) model

Background/Purpose: Rheumatoid Arthritis (RA) involves a complex interaction of multiple cell systems, cytokines and mediators. We recently developed a predictive software-based mathematical model that emulates RA pathophysiology at cellular level by incorporating the interaction of known cell systems and associated signaling and metabolic pathways.

• Read more about Isorhamnetin inhibits proliferation, invasion, and induces apoptosis through modulation of peroxisome proliferator-activated receptor-gamma activation pathway in gastric cancer.

Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.

• Read more about STAT3 is a critical mediator of the pro-survival effect of Bcl-2-Rac1 interaction in human cancer cells

Abstract 2003: STAT3 is a critical mediator of the pro-survival effect of Bcl-2-Rac1 interaction in human cancer cells

• Read more about Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.

The activation of signal transducers and activators of transcription 3 (STAT3) has been closely linked with the proliferation, survival, invasion, and angiogenesis of hepatocellular carcinoma (HCC) and represents an attractive target for therapy. In the present report, we investigated whether honokiol mediates its effect through interference with the STAT3 activation pathway.

• Read more about Amplification and demultiplexing in the insulin regulated akt pathway in adipocytes

Akt plays a major role in insulin regulation of metabolism in muscle, fat and liver. Here we show that in 3T3-L1 adipocytes, Akt operates optimally over a limited dynamic range.

• Read more about Dynamic modeling of ∝-synuclein aggregation in dopaminergic neuronal system indicates points of neuroprotective intervention: experimental validation with implications for Parkinson’s therapy

Protein aggregation is the major pathological hallmark seen in neurodegenerative disorders such as Parkinson's disease (PD). Alpha-synuclein (αS) is the main component of protein aggregates that form Lewy bodies (LBs) in PD and dementia with LBs.

• Read more about Solid pseudopapillary tumor and wnt signaling pathway...Waytogo!?

Clinical and immunohistochemical features of 34 solid pseudopapillary tumors of the pancreas

• Read more about Celastrol Inhibits Proliferation and Induces Chemosensitization through downregulation of NF-κB and STAT3 Regulated Gene Products in Multiple Myeloma Cells

BACKGROUND AND PURPOSE:

Activation of pro-inflammatory transcription factors NF-κB and signal transducer and activator of transcription 3 (STAT3) is one of the major contributors to both pathogenesis and chemoresistance in multiple myeloma (MM), which results in high mortality rate.

• Read more about Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4

BACKGROUND:

Increasing evidence indicates that the interaction between the CXC chemokine receptor-4 (CXCR4) and its ligand CXCL12 is critical in the process of metastasis that accounts for more than 90% of cancer-related deaths.