Celastrol Inhibits Proliferation and Induces Chemosensitization through downregulation of NF-κB and STAT3 Regulated Gene Products in Multiple Myeloma Cells

BACKGROUND AND PURPOSE:

Activation of pro-inflammatory transcription factors NF-κB and signal transducer and activator of transcription 3 (STAT3) is one of the major contributors to both pathogenesis and chemoresistance in multiple myeloma (MM), which results in high mortality rate.

British Journal of Pharmacology ARCHIVE