Biosimulation Using the Cellworks Computational Omics Biology Model (CBM)-Based Assessment of Cytarabine (ARA-C) and Anthracycline Response and Novel Biomarker Response Criteria for the Addition of Etoposide (VP16) in Acute Myeloid Leukemia (AML)

Background: Genomic heterogeneity in leukemic blasts characterizes Acute Myeloid Leukemia (AML) patients and is associated to variable drug response. However, use of genomics to guide therapy has generally been restricted to a single-gene approach, which rarely has sufficient predictive power to be clinically useful. Comprehensive DNA sequencing and biosimulation of the Computational Omics Biology Model (CBM) provide the opportunity and means of predicting treatment outcome in advance of treatment. ASH Annual Meeting 2021 Acute Myeloid Leukemia