Analysis of the Evolving MDS/AML Clones to Identify Resistance Mechanisms and Predict New Therapy Options at Relapse Using Computational Biology Modeling: Case-Studies from iCare1 Clinical Study

Relapse is a major challenge in treating patients with MDS and AML. In this study we used a genomics-informed computational biology modeling (CBM) technique to understand the mechanisms of relapse after chemotherapy treatment and to postulate new re-induction treatment options.