Prediction of Clinical Response for Frontline Treatment of Acute Myeloid Leukemia (AML) Patients Using the Cellworks Omics Biology Model (CBM): Mycare-021-02

Background: AML is a heterogeneous hematological cancer, characterized by the clonal expansion of myeloid blasts in the peripheral blood, bone marrow and other tissues. Among adults, AML is the leading cause of leukemia-associated death. Patients are often elderly and have comorbid conditions. Response to remission induction therapy varies by biologic subtype and by the drugs used for induction, but responses to each therapy are not predictable, even within specific biologic subgroups. To improve prognostication and identify new therapeutic options, Cellworks developed the Cellworks Omics Biology Model (CBM) that relies on multi-omics inputs from malignant cells to predict response and identify potential therapies tailored to the unique mechanisms of each patient's disease. Blood Journal 2020 Acute Myeloid Leukemia