Predictive Simulation Modeling of Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) Patient Genomics Identifies Targeted Combination Treatment Options

ETP-ALL, an orphan disease, is a subtype of T-ALL with poor prognosis and high risk of relapse after standard of care (SOC) chemotherapy. ETP-ALL is a genomically heterogeneous disease with many cases harboring complex karyotype and genetic mutations typically seen in myeloid neoplasias, such as acute myeloid leukemia (AML). 

Blood Journal 2017